Clinical evidence of AnaMel honey

AnaMel Rectal Ointment is an easy to apply ointment for the treatment of superficial wounds and chapping around the anus, as caused by haemorrhoids, for example. AnaMel Rectal Ointment consists of a relief-giving ointment and pure, enzyme-rich honey. This combination of ingredients gives the ointment its soothing and healing properties.

Skin ointment based on pure honey for relief of anal complaints

AnaMel consumer research, BAP Medical BV, The Netherlands

“Consumer Research was implementated with 30 patients who used AnaMel between 1 January 2022 and 1 April 2023.

Method : Patients answered some questions through an online questionnaire.

Conclusion: Based on the consumer research, the following conclusions about AnaMel can be drawn:

– For 90% of consumers, AnaMel meets the expectations.

– AnaMel offers relief for anal symptoms, such as itching, irritation, pain, and burning sensation.

– AnaMel feels pleasant on and offers relief for the treated skin.

– AnaMel is used on average 2 x per day”.

“The variation in bactericidal activity of 11 batches of medical-grade honey was <2-fold. Antibiotic-susceptible and-resistant isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, and Klebsiella oxytoca were killed within 24 h by 10%–40% (vol/vol) honey. After 2 days of application of AnaMel honey, the extent of forearm skin colonization in healthy volunteers was reduced 100-fold, and the numbers of positive skin cultures were reduced by 76%. AnaMel honey is a promising topical antimicrobial agent for prevention or treatment of infections, including those caused by multidrug-resistant bacteria”.

Medical‐grade honey kills antibiotic‐resistant bacteria in vitro and eradicates skin colonization

Paulus H. S. Kwakman et al, Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands

Clinical Infectious Diseases 2008, 46 (11)

Treating constitutional eczema with AnaMel Skin Ointment

Drs I. Boersma, Dermatologist, Albert Schweitzer Hospital, The Netherlands

Modern Medicine 2009, 9(4)

“This experience study shows that AnaMel Rectal Ointment reduces the symptoms of atopic eczema in the majority of patients. The main complaints that decrease in severity are erythema, excoriations, itching and insomnia. The ointment combines a soothing base ointment, for good moisture balance and restoration of the skin’s barrier function, with special anti-inflammatory, wound-healing and antibacterial effects. AnaMel Rectal Ointment can be seen as a ‘base ointment plus’ and excels in applications that support medication treatment”.

“The high sugar concentration, hydrogen peroxide, and the low pH are well-known antibacterial factors in honey and more recently, methylglyoxal and the antimicrobial peptide bee defensin-1 were identified as important antibacterial compounds in honey”.

Antibacterial components of honey (AnaMel)

Paulus H. S. Kwakman et al., Department of Medical Microbiology, Center for Infection and Immunity amsterdam (Cinima), Academic Medical Center, The Netherlands

IUBMB Life 2012, 64(1), 48–55

Two major medicinal honeys have different mechanisms of bactericidal activity

Paulus H. S. Kwakman et al., Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands

PLoS ONE 2011, 6(3)

“We assessed the bactericidal activity and mechanism of action of revamil honey (AnaMel honey) and manuka honey, the sources of two major medical-grade honeys. AnaMel honey killed Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa within 2 hours, whereas manuka honey had such rapid activity only against B. subtilis. After 24 hours of incubation, both honeys killed all tested bacteria, including methicillin-resistant Staphylococcus aureus, but manuka honey retained activity up to higher dilutions than AnaMel honey. Bee defensin-1 and H2O2 were the major factors involved in rapid bactericidal activity of AnaMel honey. These factors were absent in manuka honey, but this honey contained 44-fold higher concentrations of methylglyoxal than AnaMel honey. Methylglyoxal was a major bactericidal factor in manuka honey, but after neutralization of this compound manuka honey retained bactericidal activity due to several unknown factors. AnaMel honey and manuka honey have highly distinct compositions of bactericidal factors, resulting in large differences in bactericidal activity”.
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